Segundos tumores primarios en cáncer de cabeza y cuello / Second primary tumours in head and neck cancer

Introducción y objetivos: Los segundos tumores primarios afectan más a pacientes con cáncer de cabeza y cuello que a la población general. Con preferencia por cabeza y cuello, pulmón y esófago, afectan la supervivencia a largo plazo. El objetivo es estudiar la incidencia, localización en relación con el tumor índice y su estadio, cronología de aparición, relación con la edad del paciente y supervivencia posdiagnóstico. Material y método: Estudio retrospectivo de 579 pacientes diagnosticados de carcinoma epidermoide de cabeza y cuello, tratados con intención curativa y seguimiento mínimo de 24 meses. El 42,4% (246/579) eran estadios I y II, y el 57,6% (334/579) restante eran estadios III y IV. Resultados: El 15% (87/579) de los pacientes desarrollaron un segundo tumor, y el 9,2% (8/97) desarrollaron un tercer tumor. Las localizaciones más frecuentes fueron cabeza y cuello, 37,9% (33/87), pulmón, 36,8% (32/87), esófago, 5,7% (5/87) y colorrectal, 5,7% (5/87). La supervivencia a 5 y 10 años de pacientes sin segundo tumor fue del 65,1 y 52,7% respectivamente, frente a una 58,7 y 40,2% de los que sí lo desarrollaron. Conclusiones: La incidencia de segundos tumores se ha incrementado en los últimos años y suponen una disminución en la supervivencia de los pacientes. La revisión periódica y la reducción del consumo de alcohol y tabaco son, ante la ausencia de diagnóstico precoz efectivo, la mejor manera de reducir su incidencia (AU)

Introduction and objectives: Head and neck cancer patients have a higher risk of second primary tumours than the general population. The most frequent locations are head and neck, lung and oesophagus, decreasing long-term survival. The aim of this work was to analyse the incidence, location according to index tumour and stage, chronology, patient age, and survival after diagnosis. Method: Retrospective study on 579 patients with head and neck squamous cell carcinoma, treated with curative intent, with a minimum 24-month follow-up. Early stages (I/II) were 42.4%, and 57.6% were stages III and IV. Results: Second primary tumour incidence was 15% (87/579), with 9.2% (8/97) developing a third tumour. The most frequent locations of the second tumours were head and neck, 37.9% (33/87); lung, 36.8% (32/87); oesophagus, 5.7% (5/87); and colon, 5.7% (5/87). Five- and 10-year survival in patients without a second tumour was 65.1% and 52.7% respectively, versus 58.7% and 40.2% in those who developed one. Conclusions: The incidence of second primary tumours increased in the last decade, having a negative effect on survival. Since no specific early diagnosis tool is available, alcohol and tobacco avoidance along with scheduled follow-up are suggested procedures to reduce its incidence (AU)

Metástasis de adenocarcinoma de colédoco en laringe / Laryngeal metastasis from bile duct adenocarcinoma

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Second primary tumours in head and neck cancer. / Segundos tumores primarios en cáncer de cabeza y cuello.

INTRODUCTION AND OBJECTIVES: Head and neck cancer patients have a higher risk of second primary tumours than the general population. The most frequent locations are head and neck, lung and oesophagus, decreasing long-term survival. The aim of this work was to analyse the incidence, location according to index tumour and stage, chronology, patient age, and survival after diagnosis. METHOD: Retrospective study on 579 patients with head and neck squamous cell carcinoma, treated with curative intent, with a minimum 24-month follow-up. Early stages (I/II) were 42.4%, and 57.6% were stages III and IV. RESULTS: Second primary tumour incidence was 15% (87/579), with 9.2% (8/97) developing a third tumour. The most frequent locations of the second tumours were head and neck, 37.9% (33/87); lung, 36.8% (32/87); oesophagus, 5.7% (5/87); and colon, 5.7% (5/87). Five- and 10-year survival in patients without a second tumour was 65.1% and 52.7% respectively, versus 58.7% and 40.2% in those who developed one. CONCLUSIONS: The incidence of second primary tumours increased in the last decade, having a negative effect on survival. Since no specific early diagnosis tool is available, alcohol and tobacco avoidance along with scheduled follow-up are suggested procedures to reduce its incidence.

Minimally invasive video-assisted submandibular sialadenectomy: surgical technique and results from two institutions.

BACKGROUND: Submandibular gland excision is traditionally performed using a transcervical approach. However, innovative surgical trials have recently been conducted to investigate techniques that can prevent or reduce visible scarring and nerve injury. The aim of the present study was to evaluate the feasibility of a new approach to submandibular gland excision that is based on the use of a minimally invasive video-assisted technique and an ultrasound scalpel in an endoscopic neck surgery program with a low annual flow of procedures. METHODS: We retrospectively studied 15 patients with submandibular gland disease who underwent minimally invasive video-assisted submandibular sialadenectomy performed by two surgeons at two institutions. Eight patients had proximally located salivary calculi, three had chronic sialadenitis, and four had benign neoplasms. All dissections were carried out by a single-port gasless approach, using the Miccoli technique, involving endoscope magnification and an ultrasonic scalpel. RESULTS: All 15 submandibular gland resections were performed successfully, with no conversions to conventional open resection. The operative time ranged from 45 to 125 min (median 84 min). A total of 67 % of patients were discharged the day after surgery, and the maximum length of stay was 3 days. One patient experienced postoperative bleeding, and one experienced postoperative infection. There was no neural injury. The incision scar healed well in all cases, and all patients reported excellent cosmetic results. CONCLUSIONS: Endoscopic submandibular gland resection using a minimally invasive video-assisted technique, endoscopic magnification, and ultrasonic scalpel was feasible and resulted in excellent surgical outcomes.